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Oxcarbazepine is an antiepileptic drug used to treat seizure disorders (epilepsy). The exact mechanism of action of Oxcarbazepine and its active metabolite 10-monohydroxy metabolite (MHD) are unknown. Oxcarbazepine blocks potential-dependent sodium channels resulting in stabilization of overexcited neurons membranes, inhibition of a series of discharges in neurons and reduction of synaptic impulses. Increased K+ conductance and modulation of Ca2+ channels activated by a high potential of the membrane also invest in the antiepileptic effect of the drug. Oxcarbazepine may rarely be used for treatment of bipolar disorder (manic-depressive disorder).
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